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Description

Perrone et al., 2012)

Activation of the upstream regulator peroxisome proliferator-activated receptor (PPAR) induces the expression of ferroptosis suppressor protein 1 while simultaneously downregulating APP synthesis and inhibiting -site APP cleaving enzyme 1 hydrolytic activity, effectively reducing A oligomer generation (121)

2012 [cited 2024 Apr 18];119:242533

In accordance with our review in Clinical features or phenotypes of depression, the NIMETOX pathway is strongly associated with suicidal ideation and attempts and the severity of depression, anxiety, and chronic fatigue [140]